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Associate Professor
Cassandra Szoeke

BSc (Hons) Genet (Unimelb) MBBS (FlindersU) FRACP (RACP) PhD (Unimelb)

A/Prof. Cassandra Szoeke is the Director of the Women’s Healthy Ageing Project (WHAP) Chair of the Vascular Stream in the Australian Imaging Biomarker and Lifestyle (AIBL) study of ageing and the aiblyWHAP imaging sub-study. She led the research program in Neurodegenerative Diseases, Mental Disorders and Brain Health at the Australian Commonwealth Science and Industry Organisation (CSIRO) and then became a Clinical Consultant to CSIRO. 

Casssandra is a practicing neurologist with an honours degree in Genetics and Pharmacology, MBBS and FRACP with specialisation in Neurology and subspecialisation in Epileptology. She completed her PhD thesis in Epidemiology examining women’s healthy ageing and her post doctoral studies conducted between Stanford University and the University of Melbourne focussed on cognition. 

She has been in clinical research for over a decade with over 100 publications including more than 50 peer-reviewed publications, is a reviewer for national and international journals and funding bodies. She has been the recipient of numerous national and international awards for her research work. She brings together management skills with a scientific background in genetics, pharmacology, epidemiology, neurology and neurodegenrative disorders. She is a member of the board of executive directors for the Western Health Service Network in Melbourne.

Current Research Projects

Womens Healthy Ageing

Cognitive Decline

Pharmacogenomics and Epilepsy

Teaching Areas

General Medicine

General Neurology

Women's Health

Epilepsy

Research Areas

Healthy Ageing

Women's Health

Neurodegenerative Diseases

Other Appointments

Consultant Neurologist, Melbourne Health, Royal Park Campus

Director, Neurodegenerative Diseases, Mental Disorders and Brain Health Research in the Preventive Health Division, CSIRO.

Publications

For a full list of publications, please click here.

Frost, S., Kanagasingam, Y., Sohrabi, H., Vignarajan, J., Bourgeat, P., Salvado, O., Villemagne, V., Rowe, C.C., Lance Macaulay, S., Szoeke, C., Ellis, K.A., Ames, D., Masters, C.L., Rainey-Smith, S., Martins, R.N., (2013). Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease. TranSl Psychiatry 3: e233.

Rembach, A., Faux, N.G., Watt, A.D., Pertile, K.K., Rumble, R.L., Trounson, B.O., Fowler, C.J., Roberts, B.R., Perez, K.A., Li, Q.X., [......],. Barnham, K..J., Ellis, K.A., Szoeke, C., Macaulay, L., Rowe, C.C., Villemagne, V.L., Ames, D., Martins, R.N., Bush, A.I., Masters, C.L., (2013). Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease. Alzheimers Dement 9(13): 00009-00005.

Cyarto, E., Lautenschlager, N., Desmond, P., Ames, D., Szoeke, C., Salvado, O., Sharman, M., Ellis, K., Phal, P., Masters, C.M., Rowe, C., Martins, R.., Cox, K. (2012). Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial. BMC Psychiatry, 12(1), 167.

Doecke, J. D., S. M. Laws, Faux, N.G., Wilson, W., Burnham, S.C., Lam, C.P., Mondal, A., Bedo, J., Bush, A.I., Brown, B., De Ruyck, K., Ellis, K.A., Fowler, C., Gupta, V.B., Head, R., Macaulay, S.L., Pertile, K., Rowe, C.C., Rembach, A., Rodrigues, M., Rumble, R., Szoeke, C., Taddei, K., Taddei, T., Trounson, B., Ames, D., Masters, C.L. & Martins, R.N. (2012). Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease. Arch Neurol: 1-8.

Gardener, S., Gu, Y., Rainey-Smith, S.R., Keogh, J.B., Clifton, P.M., Mathieson, S.L., Taddei, K., Mondal, A., Ward, V.K., Scarmeas, N., Barnes, M., Ellis, K.A., Head, R., Masters, C.L., Ames, D., Macaulay, S.L., Rowe, C.C., Szoeke C., & Martins, R.N. (2012). Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population. Transl Psychiatry 2: e164.

Lim, Y. Y., Ellis, K.A., Pietrzak, R.H., Ames, D., Darby, D., Harrington, K., Martins, R.N., Masters, C.L., Rowe, C., Savage, G., Szoeke, C., Villemagne, V.L., & Maruff, P. (2012). Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology 79(16): 1645-1652.

Ryan, J.; Stanczyk, F. Z.; Dennerstein, L.; Mack, W. J.; Clark, M. S.; Szoeke, C.; Kildea, D.; Henderson, V. W. (2010). Hormone levels and cognitive function in postmenopausal midlife women. Neurobiol Aging, 33(7): 1138-1147.

Verdile, G., Laws, S.M., Laws, Henley, D., Ames, D., Bush, A.I., Ellis, K.A., Faux, N.G., Gupta, V.B., Li, Q.X., Masters, C.L., Pike, K.E., Rowe, C.C., Szoeke, C., Taddei, K., Villemagne, V.L., & Martins, R.N. (2012). Associations between gonadotropins, testosterone and beta amyloid in men at risk of Alzheimer's disease. Mol Psychiatry.

Szoeke, C., Campbell, S., Lautenschlager, N.T., Yastrubetskaya, O., & Ames, D. (2012). What’s the future of treatment for Alzheimer’s disease? Modern Medicine, 29: 20 – 32

Lim YY, Pietrzak, R.H., Ellis K, Jaeger, J., Harrington K, Ashwood, T., Szoeke, C., Martins, R.N., Bush, A.I., Masters, C., Rowe, C., Villemagne, V.L., Ames, D., Darby, D.G., & Maruff, P. (2012) Rapid decline in episodic memory in healthy older adults with high A&[beta] amyloid. Neurology (in press).

Bousman, C., Szoeke, C., Chen, K., Dennerstein, L., Henderson, V., & Everall, I. (2012). Estrogen alpha-receptor (ESR1) variant and two-year memory decline in midlife. Neuropsychobiology, 66, 258-265.

Brown, B.M., Peiffer, J.J, Taddei, K., Lui, JK., Laws, SM., Gupta, VM., Taddei, T., Ward, VK., Rodrigues, MA., Burnham, S., Rainey-Smith, SR., Villemagne, VL., Bush, A., Ellis, KA., Masters, CA., Ames, D., Macaulay, SL., Szoeke, C., Rowe, CC., Martins, RN., and the AIBL Research Group (2012). Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. MoI Psychiatry [doi: 10.1038/mp].

Yates PA, Villegmane VL, Ellis KA, Restrepo C, Martins RN, Szoeke C, Masters CL, Rowe CC for the AIBL research group (2012) Vascular risk and 11C-PiB PET: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL). Australasian Journal on Ageing; 31, S1: 16-33.

Barber B, Ames D, Ellis K, Martins R, Masters C, & Szoeke C. Lifestyle and late life cognitive health: sufficient evidence to act now? International Psychogeriatrics 2012; 24: 683-8 [doi: 10.1017/s1041610211002912]

Sona A, Zhang P, Ames D, Bush AI, Lautenschlager NT, Martins R, Masters C, Rowe C, Szoeke C, Taddei K, Ellis K and the AIBL research group. (2012). Predictors of rapid cognitive decline in Alzheimer’s disease: results from the Australian Imaging and Lifestyle (AIBL) study of ageing. International Psychogeriatrics; 24: 197 – 204

Acosta O, Fripp J, Dore V, Bourgeat P, Favreau J-M, Chételat G, Rueda A, Villemagne VL, Szoeke C, Ames D, Ellis KA, Martins RN, Masters CL, Rowe CC, Bonner E, Gris F, Xiao D, Raniga P, Barra V, Salvado O. (2011). Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer’s disease. J Neurosci Methods 2012; 205: 96-109 [doi: 10.1016/j.jneumeth.2011.12.011]

Faux NG, Ellis KA, Porter L, Fowler CJ, Laws SM, Martins RN, Pertile KK, Rembach A, Rowe CC, Rumble RL, Szoeke C, Taddei K, Taddei T, Trounson BO, Villemagne VL, Ward V, Ames D, Masters CL, the AIBL Research Group. (2012). Homocysteine, vitamin B12 and folic acid levels in Alzheimer’s disease, mild cognitive impairment and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study. J Alzheimers Dis: 27(4): 909-922.

Lim YY, Ellis K, Harrington K, Ames D, Martins R, Masters C, Rowe C, Szoeke C, Darby D, Maruff P. Use of CogState brief battery in the assessment of Alzheimer’s disease related cognitive impairment in the Australian Imaging, Biomarker and Lifestyle (AIBL) study. J Clin Exp Neuropsychol 2012; 34: 345-58